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Blow-fill-seal technology, originally developed in Europe in the 1930s and introduced in the US in the 1960s, has emerged as a preferred method for aseptic packaging of pharmaceutical and healthcare products due to unrivalled flexibility in container design, overall product quality, product output and low operational costs. The Weiler design incorporates the multi-step process of blow moulding, aseptic filling and hermetic sealing of liquid products in one sequential operation on a compact, automated machine frame with fill volumes ranging from 0.1 millilitre (ml) to 1,000ml.