Contract Solid Oral Dosage Forms Manufacturing
Available from University of Iowa Pharmaceuticals
The University of Iowa Pharmaceuticals’ (UIP) solid dosage form processing area is capable of handling batch sizes ranging from a few hundred to several hundred thousand dosage units (typically tablets or capsules). Processing capabilities include milling, sieving, high shear blending/granulation, roller compaction, low shear blending/ granulation, fluid bed granulation/coating/drying, oven drying, hard capsule filling, tablet compression, powder filling, and tablet or capsule coating. The facility is equipped with supplied breathing air, allowing full, air-tight protective gowning; has negative room pressure differentials; and single-pass, high-efficiency filtered supply and exhaust air. Each potent material handling room is equipped with a two-stage shower and gowning room. The area is fully temperature and humidity controlled, with the capability to depress humidity levels when required for hygroscopic or moisture sensitive materials.
The solid dosage forms staff has extensive experience with the production of blinded comparator products which are produced using a variety of means, including placing products into empty capsule shells and overfilling with inert powders, where appropriate, milling commercially available products and filling the resultant powder into empty capsule shells, removing ink logos from commercially available tablets or capsules, film coating over existing brand marking, or production of look-alike placebo dosage forms.