Rapid Development of an Amorphous Solid Dispersion (ASD) – Nifedipine (NIF)

Publisher: Triclinic Labs, Inc

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Rapid Development of an Amorphous Solid Dispersion (ASD) – Nifedipine (NIF)

Amorphous solid dispersions (ASD) have long been used to increase the solubility and bio-availability of poorly-soluble compounds. A considerable amount of research has been car-ried out and has generated useful techniques in the area of ASD development. Surprisingly, the number of examples with successful application of the available techniques has been meager. Herein, a case study with nifedipine is presented where ASD candidates were rap-idly determined within 2-3 weeks by utilizing a compilation of these techniques. Keywords: Amorphous Solid Dispersion (ASD), Spray Drying, Crystallization, Solubility, Sta-bility, Dissolution

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