Amorphous Solid Dispersion Development

Amorphous Solid Dispersion Development

We specialize in spray drying and amorphous solid dispersion (ASD) development services to enhance the solubility and bioavailability of poorly soluble active pharmaceutical ingredients (APIs). Using advanced techniques like spray drying and hot melt extrusion, we provide tailored solutions to create amorphous dispersions that overcome the limitations of traditional solid-state methods, such as salt formation or cocrystallization, for challenging molecules. Equipped with a state-of-the-art ProCept spray dryer, we can quickly and efficiently produce amorphous materials with as little as 500 mg of API, ensuring minimal material waste while delivering high-quality results. Our experts evaluate critical factors such as API crystallization tendencies, polymer selection from a proven toolbox of additives, optimal drug loading, and stability under various environmental conditions to ensure superior performance during in vitro dissolution studies. By partnering with us, you gain access to decades of solid-state development expertise and cutting-edge equipment that enable your formulations to succeed from early development to commercialization.