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Polymorphs and Salts-Screening & Selection
We specialize in providing advanced polymorph screening, salt selection, and chemical property improvement services to...
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Cocrystal - Screening Selection, and Formulation Development
We specialize in cocrystal screening, selection, and formulation development to enhance the performance of your active...
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Non-Crystalline (Amorphous) Materials Characterization, Stability Prediction, Development
We offer specialized characterization and development services for non-crystalline (amorphous) materials, helping you...
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Amorphous Solid Dispersion Development
We specialize in spray drying and amorphous solid dispersion (ASD) development services to enhance the solubility and...
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Crystallization Method Development
We provide comprehensive crystallization method development and optimization services to ensure your active...
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Particle and Habit Engineering
We offer comprehensive particle analysis and materials characterization services to help your business optimize product...
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Chemical Property Improvement & Problem Solving
We specialize in solid-form problem solving and consulting, offering tailored solutions to overcome challenges such as...
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Predictive Materials Modeling
Our Materials Modeling Group leverages advanced computational prediction and design capabilities to guide your product...
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Developing GMP Methods for Solid Analysis
We offer comprehensive cGMP analytical method development, validation, and lot release testing services, specializing...
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A Comprehensive Approach for Solid Form Selection in Preclinical Development and Beyond.
Different solid forms (polymorphs, salts, cocrystals) of an active pharmaceutical ingredient (API) can have very...
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Rapid Development of an Amorphous Solid Dispersion (ASD) – Nifedipine (NIF)
Amorphous solid dispersions (ASD) have long been used to increase the solubility and bi-oavailability of poorly-soluble...
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Microcrystal Electron Diffraction Study of Multi-component Salt and Cocrystal Forms of 3-Nitrobenzoic Acid and Pyrimethanil
Three single-phase crystals containing 3-nitrobenzoic acid (NBA) and pyrimethanil (PYR) in a 1:1 stoichiometry were...
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Utility of Low Frequency (LF) Raman Mapping: Dissolution of Acetaminophen (ACE) Spray Dried Dispersions (SDD)
This application note outlines the evaluation of post-dissolution ACE SDD. The results indicated that in all of the...
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Cocrystals: A Regulatory Rebirth
What is the impact of recent changes in FDA guidance on regulatory and intellectual property issues? The FDA...
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In situ observation of Theophylline anhy-drous forms II, III, V, and I* using Variable-Temperature, Variable-Relative Humidity Powder X-ray Diffraction
Theophylline was investigated using an Anton Paar Controlled Humidity Chamber (CHC+) attachment on a Rigaku SmartLab...
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Novel Non-Crystalline Materials Analysis: New Strategies to De-risk Amorphous Material Formulation D
The latest approaches for characterizing non-crystalline (amorphous) materials and determining physical stability under...
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Application of Low-Frequency (LF) Raman Spectroscopy to an Isoenergetic Polymorph Study
The importance of polymorphism in the pharmaceutical industry is well established. Much literature exists describing...
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