Utility of Low Frequency (LF) Raman Mapping: Dissolution of Acetaminophen (ACE) Spray Dried Dispersions (SDD)

Publisher: Triclinic Labs, Inc

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Utility of Low Frequency (LF) Raman Mapping: Dissolution of Acetaminophen (ACE) Spray Dried Dispersions (SDD)

This application note outlines the evaluation of post-dissolution ACE SDD. The results indicated that in all of the cases studied, ACE remained amorphous upon dissolution if it was intimately mixed in the dispersion. However, phase separation from the polymer allowed ACE to crystallize as expected. Interestingly, the type of polymer used affected the ACE polymorph generated. The mixture of polymorphs was observed in the powder X-ray diffraction (PXRD) result (though it could easily be overlooked), while LF Raman maps showed distinct regions of the different polymorphs. This study demonstrated the utility of LF Raman mapping in elucidating the dissolution mechanism of amorphous dispersions. Keywords: Low Frequency Raman, Amorphous, Spray dried dispersion, Dissolution, Crystallization, Polymorphs

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