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Application of Low-Frequency (LF) Raman Spectroscopy to an Isoenergetic Polymorph Study

Available from Triclinic Labs, LLC

Application of Low-Frequency (LF) Raman Spectroscopy to an Isoenergetic Polymorph Study

Content Summary

The importance of polymorphism in the pharmaceutical industry is well established. Much literature exists describing the effect of polymorphs on efficacy, the phenomenon of polymorphism, and the analytical tools available to study polymorphism in active pharmaceutical ingredients and drug products. Standard analytical techniques in the study of polymorphism include x-ray diffraction, differential scanning calorimetry, thermogravimetry, vapor sorption analysis, vibrational spectroscopy, and solid-state nuclear magnetic resonance spectroscopy. Here we discuss the use of low frequency (THz) Raman spectroscopy for differentiation of solid forms.

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